Heal for a percentage of damage dealt with your abilities. Increases with each unique takedown.
Offense
+1-10% CDR
Flex
+5 AD or 9 AP
Defense
+6 Armor or 8 MR (match-up)
WhyPhase Rush
Phase Rush on Vladimir allows you to chase down and position for a second round of spell rotations. Vlad can be easily kited and Phase Rush helps mitigate that.
Proc Phase Rush with a Auto->[Q]->[E] or with [R] in teamfights.
WhyNimbus Cloak
Nimbus Cloak's massive movement speed burst is fantastic for opening up on a teamfight flank and taking over the game.
WhyTranscendence
The biggest gate to Vlad's power is his cooldowns. Having spells up more often means more damage, more health, and more safety with [W].
Transcendence allows you to hit 40% CDR in the mid-game with Protobelt, CDR boots, and Zhonya's.
WhyGathering Storm
Gathering Storm on Vlad makes you an unstoppable late-game monster if you're able to get to 3+ items.
WhyTaste of Blood
Taste of Blood on Vlad allows you further pressure your lane opponent through attrition of health.
Taking trades with your empowered [Q] with Taste of Blood, Ravenous Hunter, and Scorch makes it very difficult for the enemy to come out ahead.
WhyRavenous Hunter
Ravenous Hunter further empowers your ability to heal and take efficient trades.
In teamfights, with a few Hunter Stacks, the bonus healing allows you to dive for a big [R] and heal for massive amounts to get out safely.