Syndra

Middle

Unleash Power

Massive burst damage and empowered lane sustain.

Domination

Burst damage and target access

Electrocute

Hitting a champion with 3 separate attacks or abilities in 2s deals bonus adaptive damage.
Taste of Blood

Recover health when you damage an enemy champion.
Eyeball Collection

Collect eyeballs for champion and ward takedowns. Gain permanent AD or AP, Adaptive for each eyeball plus bonus upon collection completion.
Ravenous Hunter

Heal for a percentage of damage dealt with your abilities. Increases with each unique takedown.

Inspiration

Creative tools and rule bending

Biscuit Delivery

Get a free biscuit every 3 minutes, until 12 minutes. Biscuits heal and permanently increase your max mana.
Magical Footwear

You get free boots at 10 min. but you cannot buy boots before then. These boots give additional MS. For each takedown you acquire the boots 30s sooner.

WhyElectrocute

Like Thunderlords, Electrocute is a fantastic and reliable source of damage thanks to her semi-long range abilities and auto-attack range.

WhyTaste of Blood

As Syndra you are easily able to proc Taste of Blood in lane while on the move, with [Q], without taking an damage. This easy proc helps sustain and out-trade enemies for lane dominance

WhyEyeball Collection

Eyeball Collection is the go-to rune for snowballing a lead from a kill, especially on a champion like Syndra who can take over by one-shotting an enemy squishy.

WhyRavenous Hunter

Ravenous Hunter allows you to effectively trade in lane with constant harassment damage from [Q] while healing a bit in return.

WhyBiscuit Delivery

Biscuit Delivery offers incredible lane sustain and the ability to constantly trade damage with the enemy while staying ahead of them

WhyMagical Footwear

Magical Footwear is an all-around great rune choice as the gold efficiency is equivalent to a free kill in the early game.