So many souls await

  1. Offense

    +5 AD or 9 AP

  2. Flex

    +5 AD or 9 AP

  3. Defense

    +6 Armor

WhyDark Harvest

Dark Harvest's execution damage play pattern synergizes well with Karthus' [R] when you're looking to pick up late-hit kills.

WhyTaste of Blood

Taste of Blood makes your lane phase sustain a lot more reliable.

WhyEyeball Collection

Eyeball Collection's kill/assist stacking is easy to build up with a few early well-timed [R]s.

WhyUltimate Hunter

Ultimate Hunter is the perfect rune choice here for Karthus as the stacks are easy to pick up across the map with [R] as well as keeping your main ability on as short of a cooldown as possible.

WhyPresence of Mind

Like Ultimate Hunter, this build is entirely focus around your [R] execute damage and keeping on as low of a cooldown as possible.

WhyCoup De Grace

Coup De Grace further empowers your ability to lat hit champions with [R], especially when combined with Dark Harvest.

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