Twitch

Bottom

Rat-Ta-Tat

Massive sustain and lane trade damage.

Precision

Improved attacks and sustained damage

Lethal Tempo

1.5s after damaging a champion gain a large amount of attack speed. Lethal Tempo allows you to temporarily exceed the attack speed limit.
Triumph

Takedowns restore health and grant bonus gold.
Legend: Alacrity

Takedowns on enemies grant permanent Attack Speed.
Coup De Grace

Deal 7% more damage to low health champions. Gain AD/AP after kills or assists.

Sorcery

Empowered abilities and resource manipulation

Absolute Focus

While above 70% health, gain up to +40 Ability Power or +28 Attack Damage (based on level), Adaptive.
Gathering Storm

Gain increasing amounts of AD or AP, Adaptive over the course of the game.

Offense

+9% Attack Speed
Flex

+6 AD or 10 AP
Defense

+5 Armor

WhyLethal Tempo

Lethal Tempo on Twitch allows you to take over take-game teamfights when paired with the massive attack range and damage from your [R], to solo win the game.

WhyTriumph

Triumph acts as a largely mid-fight heal for late game teamfights where you are able to hit the majority of the enemy team with [R].

WhyLegend: Alacrity

Twitch is an AD Carry that naturally relies on getting as many auto attacks in as possible for extra damage. Alacrity will also help you build passive stacks faster in the early game for [E] burst damage.

WhyCoup De Grace

Coup De Grace is the go-to rune for reliable bonus damage. Paired with the burst of [E], Twitch's damage can scale incredibly well with a small lead.

If you're playing into a number of tanks (Jungle, Top, Support) Cut Down can be a great alternative thanks to your ability to hit multiple target in a teamfight with [R].

WhyAbsolute Focus

The bonus AD granted from Absolute Focus is huge for empowering your damage opener when coming out of stealth as well as those late game teamfights before you are targeted.

WhyGathering Storm

Gathering Storm is your late-game insurance policy. In a 40min+ game you will be bale to potentially take over a teamfight with a well positioned [R].