Teamfight/skirmish utility and mid-game power.
Empowered abilities and resource manipulation
Your attacks and abilities send Aery to a target, damaging or shielding allies.
Hitting enemy champions with a spell grants maximum mana.
After reaching 250 mana, Manaflow Band restores 1% of your missing mana every 5 seconds.
Gain 10% CDR when you reach level 10. Excess CDR becomes AP or AD, Adaptive.
Gain increasing amounts of AD or AP, Adaptive over the course of the game.
+20 Ability Power or +12 Attack Damage, Adaptive
Start the game with 6 Minion Dematerializers. Killing minions with the item gives permanent bonus damage vs. that minion type.
+5% Max CDR
+5% Summoner Spell CDR
+5% Item CDR
Summon Aery is a fantastic choice for Karma Mid as you're able to effectively proc it offensively for more damage as well as defensively for a massive shield on a teammate thanks to your AP scaling.
Manaflow Band on Karma is fantastic for sustaining your mana in the mid-game for constant harass and ability utility spam in teamfights.
Transcendence allows you to hit that critical 45% CDR in the mid-game with Luden's and Chalice while still allowing you to build Sorc shoes for extra damage.
Karma has very good AP scaling on her [Q] and [E] making her super late game [R]->[E] a potential teamfight winning ability.
Minion Dematerializer helps empower your early wave clear so that you can keep up with your enemy laner to get to Luden's without getting out-roamed.
Cosmic Insight's general utility is a fantastic choice for empowering you both offensively as well as defensively with [E].