Teamfight/skirmish utility and mid-game power.
Empowered abilities and resource manipulation
Your attacks and abilities send Aery to a target, damaging or shielding allies.
Hitting enemy champions with a spell grants maximum mana.
After reaching 250 mana, Manaflow Band restores 1% of your missing mana every 5 seconds.
Gain 10% CDR when you reach level 10. Excess CDR becomes AP or AD, Adaptive.
Gain increasing amounts of AD or AP, Adaptive over the course of the game.
Creative tools and rule bending
Start the game with 6 Minion Dematerializers. Killing minions with the item gives permanent bonus damage vs. that minion type.
+5% Max CDR
+5% Summoner Spell CDR
+5% Item CDR
+5 AD or 9 AP
+6 Armor or 8 MR (match-up)
Summon Aery is a fantastic choice for Karma Mid as you're able to effectively proc it offensively for more damage as well as defensively for a massive shield on a teammate thanks to your AP scaling.
Manaflow Band on Karma is fantastic for sustaining your mana in the mid-game for constant harass and ability utility spam in teamfights.
Transcendence allows you to hit that critical 45% CDR in the mid-game with Luden's and Chalice while still allowing you to build Sorc shoes for extra damage.
Karma has very good AP scaling on her [Q] and [E] making her super late game [R]->[E] a potential teamfight winning ability.
Minion Dematerializer helps empower your early wave clear so that you can keep up with your enemy laner to get to Luden's without getting out-roamed.
Cosmic Insight's general utility is a fantastic choice for empowering you both offensively as well as defensively with [E].