Hard engage suitability and teamfight takeover.
Durability and crowd control
After immobilizing an enemy champion gain defenses and later deal a burst of adaptive damage around you.
After taking damage from an enemy champion, the next 3 spells or attacks you receive deal less damage.
Start the game with extra health. After 4 takedowns, consume that health for adaptive AD or AP.
Every 8 monsters or enemy minions that die near you permanently increases your max health by 0.2%.
+65 health and +10 AP or 6 AD, adaptive
Hitting enemy champions with a spell grants maximum mana.
After reaching 250 mana, Manaflow Band restores 1% of your missing mana every 5 seconds.
Gain 10% CDR when you reach level 10. Excess CDR becomes AP or AD, Adaptive.
Aftershock on Lissandra allows you to hard-engage with [E]->[W] and get a bunch of defenses until you [R] and Zhonya's, making you unkillable for a long period of time.
Bone Plating's burst damage reduction is great for those moments when you engage for your team and are not able to get a self [R] off immediately.
Chrysalis' early health is great for trading in lane as well as the extra AP always helps to get more kills and snowball a lead.
Overgrowth's extra HP synergizes well with Lissandra's item build of Protobelt and Morello's to grant you a decent amount of extra health.
Manaflow Band paired with Lissandra's passive is your main source of mana regen, allowing you to forgo the need to purchase a mana item.
Early CDR is especially useful on Lissandra and is results in a lot more damage throughput from [Q] and well as CC with [W].