Garen

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Demacian Justice for All

Efficient early lane trades and kill secure with [R].

Resolve

Durability and crowd control

Grasp of the Undying

Every 4s your next attack on a champion deals bonus damage, heals you, and permanently increases your health.
Bone Plating

After taking damage from an enemy champion, the next 3 spells or attacks you receive deal less damage.
Conditioning

After 10 minutes gain 8 Armor and 8 Magic Resist and increase your total Armor and Magic Resist by 5%.
Unflinching

Increase your Tenacity and Slow Resistance for each summoner spell on cooldown. Immediately after casting a Summoner Spell, gain a larger burst of Tenacity and Slow Resistance for a moderate duration.

Sorcery

+65 health and +10 AP or 6 AD, adaptive

Celerity

Gain 3% extra MS. Gain extra AP or AD, based on your bonus MS, Adaptive.
Gathering Storm

Gain increasing amounts of AD or AP, Adaptive over the course of the game.

WhyGrasp of the Undying

Unfortunately Garen doesn't have any fantastic keystone choices, Grasp is just the best of the bad.

You should be able to proc Grasp relatively easily in melee matchups with [Q] and the bonus max health synergizes well with your [W].

WhyBone Plating

Bone Plating massively empowers your ability to take aggressive trades early in lane while mitigation most incoming damage.

WhyConditioning

Conditioning allows you to scale into the mid game as a very threatening tank.

Strong AD Matchups: If playing into a strong AD matchup like Renekton or Camille, take Iron Skin.

Strong AP Matchups: If playing into a strong AP matchup like Rumble, take Mirror Shell.

WhyUnflinching

The bonus tenacity and slow resistance will help you overcome Garen's biggest pitfall of getting kited by CC and slows.

With Unflinching you should be able to stick to your target for the kill much more easily.

WhyCelerity

Celerity's ability to massively buff your AD when paired with the bonus movement speed from [Q] and Phage make you a monster carry able to dish out a ton of damage throughout the game.

WhyGathering Storm

Gathering Storm help to scare you offensively into late games while still being able to itemize defensively.