Lissandra

Middle

Another Frozen Corpse

Lane pressure harass and utility.

Sorcery

Empowered abilities and resource manipulation

Arcane Comet

Hitting a champion with spells hurls a comet that deals adaptive damage at them. Landing more spells reduces Arcane Comet's cooldown.
The Ultimate Hat

Gain cooldown reduction and max cooldown reduction on your ultimate. This is increased further each time you use your ultimate, up to a maximum.
Absolute Focus

While above 70% health, gain up to +40 Ability Power or +28 Attack Damage (based on level), Adaptive.
Scorch

Your first ability hit every 20s burns champions.

Inspiration

+20 Ability Power or +12 Attack Damage, Adaptive

Perfect Timing

Gain a free stopwatch. Stopwatch has a one time use Stasis active.
Cosmic Insight

+5% CDR
+5% Max CDR
+5% Summoner Spell CDR
+5% Item CDR

WhyArcane Comet

Arcane Comet is a relatively abusable keystone for Lissandra thanks to the very short cooldown and slow on [Q]. [Q] harass with Comet and Scorch will result in a lot of chip damage during lane.

WhyThe Ultimate Hat

The Ultimate Hat grants Lissandra fantastic safety and kill pressure. At 45% CDR and max Hat stacks, your ult is down to 32s.

WhyAbsolute Focus

Absolute Focus empowers your ability to harass in lane with long range [Q]s through the minion wave for even more empowered damage.

WhyScorch

Scorch is a fantastic lane harass rune, and pairs incredibly well with Aery to keep the pressure up.

WhyPerfect Timing

Zhonya's is a naturally synergistic item for Lissandra, allows you to hard engage a fight for your team with [E] and buying time for yourself with [R] and the Zhonya's stasis.

WhyCosmic Insight

Cosmic Insight's general utility to great for empowering your damage output with [Q] spam as well as ensuring even more lane safety with more often Summoner Spells.