Lissandra

Middle

Another Frozen Corpse

Lane pressure, harass, and utility.

Sorcery

Empowered abilities and resource manipulation

Arcane Comet

Hitting a champion with spells hurls a comet that deals adaptive damage at them. Landing more spells reduces Arcane Comet's cooldown.
Manaflow Band

Hitting enemy champions with a spell grants maximum mana.

After reaching 250 mana, Manaflow Band restores 1% of your missing mana every 5 seconds.
Transcendence

Gain 10% CDR when you reach level 10. Excess CDR becomes AP or AD, Adaptive.
Scorch

Your first ability hit every 20s burns champions.

Domination

+20 Ability Power or +12 Attack Damage, Adaptive

Taste of Blood

Recover health when you damage an enemy champion.
Ultimate Hunter

Unique takedowns grant permanent cooldown on your Ultimate.

WhyArcane Comet

Arcane Comet is a relatively abusable keystone for Lissandra thanks to the very short cooldown and slow on [Q]. [Q] harass with Comet and Scorch will result in a lot of chip damage during lane.

WhyManaflow Band

Manaflow Band is great for empowering your lane phase harass with [Q]. A successful [Q] proc means more mana sustain and more opportunities to wear down you lane opponent.

WhyTranscendence

Transcendence's mid-game utility allows you to spec into a more raw-AP-heavy build for burst damage to take over teamfights.

WhyScorch

Scorch is a fantastic lane harass rune, and pairs incredibly well with Aery to keep the pressure up.

WhyTaste of Blood

Lissandra's ability to repeatedly deal harassment damage makes Taste of Blood an incredibly reliable lane sustain tool for frequent damage trades.

WhyUltimate Hunter

As Lissandra your [R] is an incredibly versatile tool both offensively and defensively. More ults means more kill and survival potential.