Lane pressure, harass, and utility.
Empowered abilities and resource manipulation
Hitting a champion with spells hurls a comet that deals adaptive damage at them. Landing more spells reduces Arcane Comet's cooldown.
Hitting enemy champions with a spell grants maximum mana.
After reaching 250 mana, Manaflow Band restores 1% of your missing mana every 5 seconds.
Gain 10% CDR when you reach level 10. Excess CDR becomes AP or AD, Adaptive.
Your first ability hit every 20s burns champions.
Burst damage and target access
Recover health when you damage an enemy champion.
Unique takedowns grant permanent cooldown on your Ultimate.
+6 AD or 10 AP
+5 Armor or 6 MR (match-up)
Arcane Comet is a relatively abusable keystone for Lissandra thanks to the very short cooldown and slow on [Q]. [Q] harass with Comet and Scorch will result in a lot of chip damage during lane.
Manaflow Band is great for empowering your lane phase harass with [Q]. A successful [Q] proc means more mana sustain and more opportunities to wear down you lane opponent.
Transcendence's mid-game utility allows you to spec into a more raw-AP-heavy build for burst damage to take over teamfights.
Scorch is a fantastic lane harass rune, and pairs incredibly well with Aery to keep the pressure up.
Lissandra's ability to repeatedly deal harassment damage makes Taste of Blood an incredibly reliable lane sustain tool for frequent damage trades.
As Lissandra your [R] is an incredibly versatile tool both offensively and defensively. More ults means more kill and survival potential.