Vayne
Rough and Tumble
Lane harassment and consistent damage output.
Hitting an enemy champion 3 consecutive times deals bonus damage and amplifies your damage until you leave combat with champions.
Killing a target heals you.
Takedowns on enemies grant permanent Attack Speed.Deal more damage to high health enemy champions.
While above 70% health, gain extra
adaptive damage .Gain increasing amounts of AD or AP,
adaptive over the course of the game.
Offense
+5 AD or 9 AP
Flex
+5 AD or 9 AP
Defense
+6 Armor or 8 MR (match-up)
Why Press the Attack
The auto-attack reset from [Q] allows you to quickly proc Press the Attack, especially in extended fights where you can repeatedly deal damage.
Why Absorb Life
Overheal is a good option here if you think you're going to struggle a bit in the laning phase and your support is able to provide heals either as a Melee with Targon's or a healing champion. Triumph here is mainly to keep you healthy after a kill and play up the reset nature of your **[R]**.
Why Legend: Alacrity
Vayne is all about getting as many auto attack off as possible to proc [W]. Alactrity's bonus Attack Speed also empowers you ability to proc more instances of Fleet Footwork for more healing and chase.
Why Cut Down
Cut Down is the most reliable form of damage amp for an AD Carry, largely thanks to the fact that you do not build any health items.
WhyAbsolute Focus
Absolute Focus' additional Attack Damage is great for back-line carries who can keep their health high with good kiting for additional damage output and carry potential.
WhyGathering Storm
Vayne is all about late game scaling and there is no better scaling rune than Gathering Storm. If you can make it 30min+ game you will be an unstoppable force in teamfights.