Ambessa

Glutton for Punishment

Lane harassment and consistent damage output.

HARD CODED Empowered abilities and resource manipulation

Conqueror

Gain stacks of adaptive force when attacking enemy champions. After reaching 12 stacks, heal for a portion of damage you deal to champions.
Triumph

Takedowns restore 5% of your missing health and grant an additional 20 gold.
Legend: Haste

Takedowns on enemies grant permanent Basic Ability Haste.
Last Stand

Deal more damage to champions while you are low on health.

Burst damage and target access

Sudden Impact

Damaging basic attacks and abilities deal bonus true damage to enemy champions after using a dash, leap, blink, teleport, or when leaving stealth.
Ultimate Hunter

Unique takedowns grant permanent cooldown reduction on your Ultimate.

Conqueror is a solid rune choice for Ambess because she is all about sustained bruiser fights.

Big heals in a sustain fight are the key to Ambessa staying alive and dealing damage.

Ambessa lives and dies by her getting off as many abilities as possible.

Last Stand is a great choice for extended fights where you are trying to eek out as much damage as possible.

Because Ambessa is constantly dashing around, Sudden Impact is a great choice to proc on cooldown to amplify her damage.

Ambessa's [R] is fairly string, but this rune choice is simply better than the alternatives.